Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model
نویسندگان
چکیده
منابع مشابه
Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model
Despite great advances in therapies observed during the last decades, heart failure (HF) remained a major health problem in western countries. In order to further improve symptoms and survival in patients with heart failure, novel therapeutic strategies are needed. In some animal models of HF resveratrol (RES), it was able to prevent cardiac hypertrophy, contractile dysfunction, and remodeling....
متن کاملHeart failure and greater infarct expansion in middle-aged mice: a relevant model for postinfarction failure.
Young mice tolerate myocardial loss after coronary artery ligation (CAL) without congestive heart failure (CHF) signs or mortality. We predicted a CHF phenotype after CAL in aged mice. Left coronary artery ligation produced permanent myocardial infarcts (MI). Mortality was higher in male 14-mo-old C57BL/6N mice (Older mice) than in 2-mo-old mice (Young mice) (16 of 25 Older mice died vs. 0 of 1...
متن کاملResveratrol: A Cardioprotective Agent
Today, science has a better understanding of why fruits and vegetables should be part of a healthy eating plan. Polyphenols are common constituents of the human diet, present in most foods and beverages of plant origin. They are considered to contribute to the prevention of various degenerative diseases, including cardiovascular diseases. Resveratrol is a polyphenol that occurs naturally in gra...
متن کاملCardioprotective effect of resveratrol, a natural antioxidant derived from grapes.
BACKGROUND The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wines, in the rat after ischemia and ischemia-reperfusion (I-R). METHODS The left main coronary artery was occluded for 30 or 5 min followed by a 30-min reperfusion in anesthetized rats. Animals were preinfused with and without resveratrol before occlus...
متن کاملProtective effect of resveratrol against pressure overload-induced heart failure
Transverse aortic constriction (TAC)-induced pressure overload (PO) causes adverse cardiac remodeling and dysfunction that progresses to heart failure (HF). The purpose of this study was to determine whether the potent antioxidant, resveratrol, significantly attenuates PO-induced HF in wild-type mice. Male C57BL6 mice were subjected to either sham or TAC surgery. One group of TAC mice was given...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2017
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2017/6819281